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August 22, 2025Clinical and Translational GastroenterologyOpen Access

Differential Item Functioning of the Patient Health Questionnaire-9 in Decompensated Cirrhosis

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Authors

NUNneka N. UfereCZChengbo ZengDSDaniel Shalev

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Overview

Analysis shows differing symptom expression of depression in decompensated cirrhosis patients compared to primary care, suggesting the need for tailored assessments.

Key Points

  • Positive screening rates for depression were 39% in decompensated cirrhosis patients and 30% in primary care patients, indicating a notable difference.
  • Three symptoms from the PHQ-9, including sleep problems, demonstrated significant differential item functioning in decompensated cirrhosis patients.
  • Using an Item Response Theory framework, we adjusted scores to show a potential one-point increase in screening threshold for decompensated cirrhosis patients.
  • These findings highlight that depression symptoms vary in decompensated cirrhosis versus primary care, necessitating further research on diagnostic tests.

Cite This Study

Ufere et al. (2025) studied this question.

synapsesocial.com/papers/68af73567567bf4f94fecc79https://doi.org/10.14309/ctg.0000000000000906
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Why are we still using the PHQ-9? A Historical Review and Psychometric Evaluation of Measurement Invariance2025
  2. 2Reliability and cross-group equivalence of the 8-item version of the Patient Health Questionnaire (PHQ-8) to screen for depression in adults with and without chronic pain: a nationally representative U.S. population study2025
  3. 3Evaluating the Psychometric Properties of Arabic Version of the Patient Health Questionnaire-9 (PHQ-9) among Omani Patients with End Stage Renal Disease on Dialysis2025
  4. 4Norm Development Study on the Psychosocial Functioning Questionnaire for Depression Patients2025
  5. 5Using the PHQ-9 Scale to assess depressive symptoms in patients with schizophrenia: a clinical perspective2025