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August 22, 2025Open Access

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heart

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Authors

QLQiuhan LuSun Yat-sen UniversitySTShulin TangGuangdong Academy of Medical SciencesYWYuwen WuSun Yat-sen University

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Implication

Multi-omics analysis identifies lipid metabolism changes in diabetic cardiomyopathy, suggesting targeted therapies.

Key Points

  • Significant metabolic changes are observed in patients with diabetic cardiomyopathy, indicating altered lipid metabolism.
  • Patients with diabetic cardiomyopathy showed reliance on triglyceride-derived fatty acids, impacting heart function.
  • Analysis included comprehensive transcriptomic, proteomic, and metabolomic assessments from heart tissues.
  • Findings highlight the disruption of mitochondrial function and impaired cardiac matrix repair in diabetic cardiomyopathy.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68af73567567bf4f94fecacchttps://doi.org/10.1101/2025.08.21.671651
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Also Consider

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  1. 1Mitochondrial ultrastructural pathology in diabetic cardiomyopathy: integrated analysis via scanning electron microscopy and 3D visualization imaging2025 · 15 citations
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