September 10, 2025EMBO Molecular MedicineOpen Access

Left ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy

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Discussion

Multi-omic analyses reveal lipid metabolism disruption and oxidative stress in ischaemic cardiomyopathy with diabetes.

Downregulation of fatty acid transport proteins occurred in ischaemic cardiomyopathy with diabetes, suggesting lipid metabolism issues.
Findings highlight oxidative phosphorylation and myofibrosis exacerbation mainly linked to ischaemic cardiomyopathy with diabetes.
Pre-mortem human left ventricular myocardium samples were analyzed to uncover the molecular profile of ischaemic and non-ischaemic cases.
These results indicate diabetes complicates heart failure pathology, necessitating new perspectives on lipid metabolism.

Hunter et al. (2025) studied this question.

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