August 20, 2025International Journal of Environmental Sciences

Sustainable and Economical in Vitro Analytical Method Development and Validation of Tedizolid Phosphate in Rabbit Plasma Using RP-HPLC Follows ICH M10 Guidelines

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Authors

DSD. Sagar MSMeenakshi Sharma

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Implication

Analytical method finds reliable measurement of tedizolid phosphate in rabbit plasma, highlighting its use in therapeutic drug monitoring and pharmacokinetics.

Key Points

The method accurately measures tedizolid phosphate concentrations, achieving R² values above 0.999 across a range of 75 – 3000 ng/ml.
Using rp-hplc with an Agilent C18 column, the method ensures effective separation of tedizolid phosphate from plasma interference at a wavelength of 252 nm.
Samples prepared via centrifugation demonstrated strong validation parameters, confirming selectivity and robustness as per ich guidelines.
This bioanalytical method supports therapeutic drug monitoring and enhances research into pharmacokinetics and toxicology.

Cite This Study

Sagar et al. (2025) studied this question.

synapsesocial.com/papers/68af73567567bf4f94feca29 https://doi.org/10.64252/dvv23633

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Implication

Analytical method finds reliable measurement of tedizolid phosphate in rabbit plasma, highlighting its use in therapeutic drug monitoring and pharmacokinetics.

Sustainable and Economical in Vitro Analytical Method Development and Validation of Tedizolid Phosphate in Rabbit Plasma Using RP-HPLC Follows ICH M10 Guidelines

Discussion

Member takes

Implication

Key Points

Cite This Study

Sustainable and Economical in Vitro Analytical Method Development and Validation of Tedizolid Phosphate in Rabbit Plasma Using RP-HPLC Follows ICH M10 Guidelines

Discussion

Member takes

Implication

Key Points

Cite This Study

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