Sustainable And Economical in-Vitro Bio Analytical Method Development and Validation of Azelnidipine in Rabbit Plasma Using RP-UPLC Follows ICH Guidelines M10

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A validated bioanalytical method detects azelnidipine in rabbit plasma, suggesting its utility for pharmacokinetics and therapeutic monitoring.

The method accurately measures azelnidipine levels in rabbit plasma, demonstrating robust precision and reliability.
The standard curve showed linearity (R² > 0.999) in the range of 2 – 80 ng/ml, ensuring effective quantification.
Using UPLC with a specific mobile phase, the method maximizes separation efficiency and minimizes interference from plasma.
Success with this method could enhance studies in pharmacokinetics, bioequivalence, and therapeutic drug monitoring.

Pinaka et al. (2025) studied this question.

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A validated bioanalytical method detects azelnidipine in rabbit plasma, suggesting its utility for pharmacokinetics and therapeutic monitoring.