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August 21, 2025Open Access

Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes.

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Authors

LDLucy DillonJMJames O. McInerneyCCChristopher J. Creevey

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Overview

Observational analysis reveals distinct pathways for multidrug resistance in prokaryotes, suggesting implications for treatment.

Key Points

  • Multidrug resistance genes were found across both core and accessory genomes, challenging prior beliefs.
  • E. coli exhibits mutually exclusive pathways to resistance, indicating varied evolutionary paths to the same phenotype.
  • Analysis employed machine learning to identify gene associations linked to multidrug resistance traits in pathogens.
  • Species-specific genomic constraints significantly influence antimicrobial resistance emergence and network patterns.

Cite This Study

Dillon et al. (2025) studied this question.

synapsesocial.com/papers/68af6d907567bf4f94feade3https://doi.org/10.1101/2025.08.20.671315
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  5. 5Phylogenetic context of antibiotic resistance provides insights into the dynamics of resistance emergence and spread2025