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September 20, 2025The Journal of Infectious DiseasesOpen Access

Phylogenetic context of antibiotic resistance provides insights into the dynamics of resistance emergence and spread

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Authors

KGKyle J. GontjesASAryan SinghSSSarah E. Sansom

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Overview

Phylogenetic analysis reveals factors behind antibiotic resistance emergence and spread in Klebsiella pneumoniae, suggesting pathways for prevention.

Key Points

  • Phylogenetic analysis reveals distinct pathways of antibiotic resistance emergence and spread.
  • Among 386 Klebsiella pneumoniae isolates, factors include de novo evolution and cross-transmission.
  • Logistic regression identified comorbidities and medical devices as unique risk factors for resistance spread.
  • Exposure to specific antibiotics significantly impacts resistance emergence and spread among patients.

Cite This Study

Gontjes et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79efehttps://doi.org/10.1093/infdis/jiaf478
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