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July 13, 2025Open Access

Function-specific epistasis shapes evolutionary trajectories towards antibiotic resistance

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Authors

GPGabriela PetrungaroTFTheresa FinkBFBooshini Fernando

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Overview

Experiments reveal that function-specific epistasis alters resistance trajectories in Escherichia coli, suggesting new treatment strategies.

Key Points

  • Evolution of antibiotic resistance is largely repeatable across genetic backgrounds.
  • Function-specific epistasis affects the trajectory of resistance evolution in Escherichia coli.
  • Robotic evolution experiments were used to analyze resistance to three clinically relevant antibiotics.
  • Disrupting certain cellular functions can slow down the evolution of resistance, offering treatment insights.

Cite This Study

Petrungaro et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbf88https://doi.org/10.1101/2025.07.09.663857
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