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August 21, 2025

Protective Effect of Wogonin Against Colistin-Induced Nephrotoxicity in Wistar Rats: A Controlled Experimental Study

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Authors

ATAhmet Salih TüzenBGBirzat Emre GölboyuMCMehmet Ali Coşar

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Overview

Controlled study shows wogonin reduces nephrotoxicity in Wistar rats treated with colistin, indicating its potential as a nephroprotective agent.

Key Points

  • Wogonin treatment significantly reduced biomarkers of kidney injury in colistin-treated rats, highlighting its protective role.
  • Colistin induced significant elevations in BUN and creatinine, which were mitigated by wogonin treatment over ten days.
  • Analysis included biochemical, molecular, and histopathological evaluations to assess kidney health and injury.
  • Findings support the need for nephroprotective strategies in patients requiring colistin, with potential implications for clinical practice.

Cite This Study

Tüzen et al. (2025) studied this question.

synapsesocial.com/papers/68af6d8a7567bf4f94fead1ehttps://doi.org/10.21203/rs.3.rs-7124382/v1
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Also Consider

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