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June 27, 2026Indian Journal of Pharmacology

Morin ameliorates lipopolysaccharide-induced acute kidney injury in rats via alteration of TLR4/NF-κB, COX-2/PGE2, and monocyte chemoattractant protein-1/CXCL1 signaling pathway

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Authors

YWYuan WangQGQing GaoBHBo Hu

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Overview

Randomized trial demonstrates morin's protective effect on kidney function in rats, suggesting a therapeutic strategy for AKI.

Key Points

  • This study aims to investigate the protective effects of morin on acute kidney injury induced by lipopolysaccharide in rats.
  • Induced acute kidney injury using intraperitoneal LPS (10 mg/kg) in rats.
  • Administered morin orally at doses of 5, 10, and 15 mg/kg.
  • Measured various renal parameters, inflammatory cytokines, and mRNA expressions to assess kidney health.
  • Morin treatment improved body weight and reduced renal weight and renal index significantly.
  • Significant changes in renal parameters including creatinine and blood urea nitrogen were observed after morin administration.
  • Alterations in cytokine levels and expression of relevant signaling pathways were noted, indicating a protective mechanism of morin.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a3f68a3aea7db3c1953fa74https://doi.org/10.4103/ijp.ijp_975_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ranolazine is associated with attenuation of lipopolysaccharide-induced acute kidney injury via modulation of inflammatory, oxidative, and vascular markers2026
  2. 2Hepatoprotective Effect of Morin Against Lead‐Induced Oxidative Stress and Structural Alterations in Male Wistar Rats: An In Vivo and In Silico Approach2025 · 3 citations
  3. 3Suppression of nF-κB by ro 106-9920 alleviates ischemia/reperfusion-induced renal dysfunction and inflammation via modulation of neutrophil extracellular trap formation in acute kidney injury mice2025
  4. 4Morusin Alleviates Spinal Cord Injury in Rats by Regulating Macrophage Reprogramming Through Targeting <scp>RELA</scp> and <scp>NRF2</scp>2025
  5. 5Protective Effect of Wogonin Against Colistin-Induced Nephrotoxicity in Wistar Rats: A Controlled Experimental Study2025