Analysis of microbial community reveals significant patterns in children with severe pulmonary infection, indicating potential for targeted treatments.
Key Points
Significantly higher bacterial abundance is found in bronchoalveolar lavage fluid compared to blood or cerebrospinal fluid, indicating critical microbial differences.
Neonatal bronchoalveolar lavage fluid shows simplified microbiota, while older children exhibit increased diversity and distinct microbial patterns.
Sepsis samples display reduced microbial diversity with notable enrichments of Staphylococcus and Moraxella, which may influence clinical outcomes.
Ecological targeted therapy based on microbiota co-occurrence networks may improve diagnostic and treatment strategies for severe infections.