Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2025World Journal of Clinical Oncology

GPR81 nuclear transportation is critical for cancer growth and progression in lung and other solid cancers

View Full Paper
Ask AI
Bookmark
Share

Authors

LYLibang YangTKThomas J. Y. KonoAGAdam Gilbertsen

Discussion

Loading...

Member takes

Overview

Experimental analysis reveals GPR81's role in cancer malignancy through nuclear transport, indicating potential therapeutic avenues.

Key Points

  • GPR81 nuclear translocation significantly promotes cancer cell growth and invasion, especially in lung cancers.
  • Lactate stimulation drives GPR81 to the nucleus, enhancing malignancy by interacting with proteins like SFPQ.
  • Proteomics analysis identifies key proteins that interact with GPR81 in the cancer cell nucleus, influencing tumor dynamics.
  • Blocking GPR81 nuclear localization reduces cancer cell proliferation and may provide insights for new cancer therapies.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68af4093cf1dd9ea359ec6a9https://doi.org/10.5306/wjco.v16.i8.107208
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Leucine‑rich repeat‑containing G protein‑coupled receptor 4 promotes proliferation, invasion and migration, and inhibits apoptosis in non‑small cell lung cancer cells2025
  2. 2The lactate-GPR81-AMIGO2 axis promotes pancreatic ductal adenocarcinoma progression and predicts poor prognosis2026
  3. 3Glycolysis drives vascular hyperpermeability in acute lung injury via lactate-GPR81 axis in endothelial cells2026
  4. 4The Role of Lactate Metabolism in Tumors2025 · 6 citations
  5. 5Heterogeneous Nuclear Ribonucleoprotein A/B Drives Gastric Cancer and EMT via Akt-GSK3β-Wnt Pathway2025