Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 19, 2026Cell Communication and SignalingOpen Access

Glycolysis drives vascular hyperpermeability in acute lung injury via lactate-GPR81 axis in endothelial cells

View Full Paper
Ask AI
Bookmark
Share

Authors

KCKun ChenKFKerui FanYWYi-Xiang Wang

Discussion

Loading...

Member takes

Overview

Randomized trial investigates the lactate-GPR81 axis in acute lung injury, implying a novel therapeutic target for treatment.

Key Points

  • This research aims to explore how glycolysis and the lactate-GPR81 axis affect inflammation in acute lung injury.
  • Investigated the role of lactate-GPR81 axis in mice with LPS-induced acute lung injury.
  • Utilized pharmacological suppression of glycolysis and lactate supplementation to observe effects on lung injury.
  • Conducted RNA-seq analysis on endothelial cells after lactate supplementation.
  • LPS challenge resulted in increased lactate levels in bronchoalveolar lavage fluid.
  • Pharmacological inhibition of glycolysis decreased lactate and alleviated lung injury (p<0.05).
  • Global deletion of GPR81 alleviated lung injury, while lactate supplementation exacerbated it.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a5c6939118b92953e3edb37https://doi.org/10.1186/s12964-026-03070-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global Lactylome Reveals Lactylation‐Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome2025 · 3 citations
  2. 2Knockdown of ARHGDIB promotes autophagy and reduces inflammation in LPS-induced alveolar epithelial cells via the PRKACB/NF-κB pathway2025
  3. 3Histone Lactylation Exacerbates Acute Lung Injury in Septic Mice by Promoting Ferroptosis in Pulmonary Microvascular Endothelial Cells2025
  4. 4Aerobic Exercise Regulating Arterial Function by Lactate/GPR81 Signaling Pathway2025
  5. 5GPR81 nuclear transportation is critical for cancer growth and progression in lung and other solid cancers2025