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July 1, 2025International Journal of Applied and Basic Medical Research

Role and Mechanism of Astragalus Monomer Quercetin in Modulating Akt/Bcl-2 Pathway to Improve Ventricular Remodeling in Chronic Heart Failure

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Authors

SHSailing HuLLLingchun LvWHWuming Hu

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Overview

Observational analysis shows quercetin enhances cardiomyocyte survival in heart failure models, suggesting it may improve ventricular remodeling and cardiac function.

Key Points

  • Quercetin significantly improves cardiomyocyte survival and reduces myocardial fibrosis in heart failure models,% suggesting potential therapeutic benefits for chronic heart failure.
  • Enhanced cardiac function and decreased ventricular remodeling were observed in HF rats treated with quercetin, demonstrating its efficacy in modulating the Akt/Bcl-2 pathway.
  • This study utilized H/R injury models in H9C2 cells and aortic constriction-induced heart failure in rats to assess quercetin's cardioprotective effects.
  • Results support quercetin's potential as a treatment strategy for chronic heart failure by targeting apoptosis and cellular function.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68af3e49cf1dd9ea359eb63bhttps://doi.org/10.4103/ijabmr.ijabmr_97_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astragalus Polysaccharide Improves Myocardial Fibrosis in Hypertrophic Cardiomyopathy Through the TGF-β1/Smad3 Signal Pathway2025 · 2 citations
  2. 2Evidence Synthesis and Mechanism Analysis of Quercetin Treatment for Atherosclerosis: A Preclinical Systematic Review and Meta-Analysis2026 · 1 citations
  3. 3Quercetin improves myocardial ischemia–reperfusion injury by regulating macrophage M2 polarization through Bcl-2/Beclin-1 complex2025
  4. 4Astragaloside IV inhibits MAPK pathway and promotes mitochondrial autophagy in rats with heart failure2025
  5. 5Computational Modeling of Network Topology and Molecular Dynamics for the Assessment of Therapeutic Potential of the Astragalus Membranaceus-Salvia Miltiorrhiza Drug Pair in the Treatment of Chronic Kidney and Heart Failure2025