September 23, 2025

Computational Modeling of Network Topology and Molecular Dynamics for the Assessment of Therapeutic Potential of the Astragalus Membranaceus-Salvia Miltiorrhiza Drug Pair in the Treatment of Chronic Kidney and Heart Failure

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Discussion

Bioinformatics analyzed the therapeutic potential of ashwagandha and salvia in CKD and CHF, highlighting their molecular mechanisms.

The combination of astragalus membranaceus and salvia miltiorrhiza shows promise in treating chronic kidney and heart failure.
Seven core targets like AKT1 and TP53 were identified, along with 70 active ingredients from both herbs.
Protein-protein interaction analysis yielded insights into regulating molecular mechanisms for chronic kidney disease.
The study employed bioinformatics and molecular dynamics to evaluate diagnostic efficiency using receiver-operating characteristic curves.

Liu et al. (2025) studied this question.

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