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November 8, 2025Frontiers in Bioscience-LandmarkOpen Access

Astragalus Polysaccharide Improves Myocardial Fibrosis in Hypertrophic Cardiomyopathy Through the TGF-β1/Smad3 Signal Pathway

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Authors

NQNana QinWWWenjun WuBLB Li

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Overview

Observational analysis revealed significant improvements in cardiac dysfunction and myocardial fibrosis with Astragalus polysaccharide, indicating potential in Hypertrophic Cardiomyopathy treatment.

Key Points

  • Myocardial fibrosis was significantly reduced in mice treated with Astragalus polysaccharide, suggesting a benefit to cardiac health.
  • Echocardiography showed improved cardiac function in the high-dose Astragalus group compared to control samples.
  • The analysis utilized a model of hypertrophic cardiomyopathy in C57BL/6J mice with transverse aortic constriction for assessment.
  • Findings highlight potential for Astragalus polysaccharide in addressing myocardial fibrosis through targeting relevant pathways.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/690e8b6ca5b062d7a4e73672https://doi.org/10.31083/fbl45595
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Also Consider

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  1. 1The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis2025 · 1 citations
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  3. 3<i>Astragalus</i> Polysaccharide Activates the AKT-mTOR Pathway to Reduce ROS and Promote Intramuscular Protein Levels in Sarcopenia Mice2025
  4. 4ML216 Alleviates Age-Related Cardiac Fibrosis by Suppressing TGF-β1 Signaling Pathway2026
  5. 5Astragalus Polysaccharide Alleviates COPD‐Associated Skeletal Muscle Dysfunction Through Suppression of Inflammation and Cellular Senescence2025