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August 20, 2025World Journal of Stem Cells

Comparison of therapeutic potential of macrophage- or mesenchymal stem cell-derived exosomes in pancreatic cancer: An updated review

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Authors

DKDemet KaçaroğluNGNilgün Gürbüz

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Overview

Review compares therapeutic potential of exosomes from mesenchymal stem cells and macrophages in pancreatic cancer, suggesting areas for future research.

Key Points

  • In summary, macrophage-derived and MSC-derived exosomes showcase distinct therapeutic potentials in targeting pancreatic cancer.
  • Current studies highlight the limitations of drug delivery due to the dense desmoplastic microenvironment in pancreatic tumors.
  • This review includes an analysis of in vitro, in vivo, and clinical phase studies to evaluate exosome-based therapies.
  • Future research is needed to develop exosome therapies into clinical applications for treating pancreatic cancer.

Cite This Study

Kaçaroğlu et al. (2025) studied this question.

synapsesocial.com/papers/68af35efcf1dd9ea359ea9c5https://doi.org/10.4252/wjsc.v17.i8.107400
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic potential of mesenchymal stem cell exosomes for tumors in the digestive system: From bench to bedside2025
  2. 2From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment2025 · 7 citations
  3. 3Synthetic Mimetics of Exosomal Lipid Profile Enhance Gemcitabine Delivery in Pancreatic Cancer2025
  4. 4DEVELOPMENT OF STEM CELL-BASED CANCER THERAPY STRATEGIES2024
  5. 5Stem Cell-Derived Exosomes: A Comprehensive Review of Biomedical Applications, Challenges, and Future Directions2025