August 19, 2025Open Access

S1P3 promotes low-grade glioma progression and affects tumor microenvironment infiltration

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Investigation shows S1P3 overexpression correlates with poor survival in low-grade glioma, suggesting roles in immune cell infiltration.

S1P3 overexpression is significantly associated with poorer overall survival in patients with low-grade glioma, indicating its prognostic potential.
Gene Set Enrichment Analysis reveals that S1P3 influences key oncogenic pathways like DNA replication and MAPK signaling in glioma.
In vitro assays confirm that inhibiting S1P3 reduces glioma cell proliferation and migration, demonstrating its functional role in cancer progression.
Findings highlight S1P3's importance in tumor microenvironment immune cell infiltration, suggesting new therapeutic targets for glioma treatment.

Chen et al. (2025) studied this question.

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