October 3, 2025BMC CancerOpen Access

POLD3 knockdown effects on low-grade glioma: insights from bioinformatics and experimental validation

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POLD3 overexpression in low-grade glioma correlates with worsened clinical outcomes and immune profiles.
Data from TCGA and CGGA highlight POLD3's significance in low-grade glioma's pathogenesis and treatment.
Bioinformatics and experimental validation demonstrate POLD3's role in driving cell proliferation and invasion.
This study suggests POLD3 as a promising target for diagnosis and therapeutic strategies in low-grade glioma.

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Analysis shows POLD3's role in tumor immune microenvironment and clinical outcomes in low-grade glioma.

Yang et al. (2025) studied this question.

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