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September 5, 2025Biological and Pharmaceutical BulletinOpen Access

Potential Prognostic Markers for Glioblastoma Associated with the Glioma Immune Microenvironment

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Authors

KTKazuya TokumuraEHEiichi Hinoi

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Overview

This analysis identifies immune-related prognostic markers in glioblastoma, suggesting connections to immune response and treatment options.

Key Points

  • The study identifies 42 genes associated with poor glioblastoma prognosis, linking them to immune cell infiltration and overall survival.
  • Amongst these, 32 genes correlate with immune-related gene expression and immune cell types in glioblastoma tissue.
  • Analysis indicates COLGALT1, ITGB2, and MYL12A may serve as pivotal biomarkers for glioblastoma prognosis and therapeutic responses.
  • Findings from single-cell RNA-sequencing and spatial transcriptome highlight the role of immune microenvironment in glioblastoma progression.

Cite This Study

Tokumura et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477bf96https://doi.org/10.1248/bpb.b25-00219
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular characterization of macrophage-related prognostic factors in glioblastoma revealed by combined analysis on single-cell and bulk transcriptome data2025
  2. 2Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastoma2025 · 2 citations
  3. 3Immunological Biomarkers in Glioblastoma: Targeting T and NK Cells for Enhanced Diagnosis and Prognosis2026
  4. 4Bioinformatic Identification of a Six-Gene Biomarker Signature for Prognostic and Diagnostic Insight in Glioblastoma2025
  5. 5Identification of a prognostic signature consisting of three macrophage-related genes for glioblastoma based on bulk and single-cell transcriptomes analyses.2025 · 2 citations