Liver Sinusoidal Endothelial Cells and Their Regulation of Immunology, Collagenization, and Bioreactivity in Fatty Liver: A Narrative Review

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Liver sinusoidal endothelial cells regulate immunological responses and fibrosis in metabolic liver diseases, revealing their potential as therapeutic targets.
Immunological balance in the liver is significantly influenced by LSECs, which mitigate excessive immune activation and are involved in collagenization processes.
This narrative review explores their dysfunction in chronic liver diseases such as MASLD, which can progress to severe conditions like cirrhosis and HCC.
Results emphasize the need for further research in human 3D models for targeted therapies, given the limitations of current animal models.

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Narrative review highlights liver sinusoidal endothelial cells' role in fibrosis and immune response in MASLD.

Abdulmajeed et al. (2025) studied this question.

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