Dynamic crosstalk between HSCs and liver microenvironment: multicellular interactions in the regulation of liver fibrosis

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Liver fibrosis results from complex multicellular interactions, risking progression to cirrhosis or liver cancer.
Hepatic stellate cells (HSCs) are crucial in liver fibrosis but interactions with hepatocytes and immune cells are significant.
The review summarizes the impact of various liver cell types on fibrosis development and their interactions with HSCs.
Understanding these cellular interactions could lead to effective treatment strategies for liver fibrosis.

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Review uncovers multicellular interactions influencing liver fibrosis, highlighting roles of HSCs and immune cells.

Wang et al. (2025) studied this question.

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