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June 14, 2026Blood AdvancesOpen Access

Analysis of cell-free DNA in lymphomas: from sample collection to genotyping and minimal residual disease monitoring

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Authors

DPDeborah PiffarettiCCChiara ConsoliDRDavide Rossi

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Overview

Review analyzes ctDNA assessment methods in lymphomas, highlighting clinical utility and future challenges.

Key Points

  • The aim is to evaluate the use of circulating tumor DNA (ctDNA) as a tool for monitoring lymphomas and assessing minimal residual disease.
  • Discussed various methods for ctDNA assessment, including droplet digital PCR and next-generation sequencing.
  • Explored pre-analytical and analytical workflows from blood collection to genotyping.
  • Outlined the importance of quality control and standardization in clinical applications.
  • ctDNA demonstrates high potential for non-invasive molecular profiling and monitoring treatment response.
  • Establishing ctDNA as a clinical-grade assay is a priority and requires standardization across procedures.
  • Large trials are in progress to validate ctDNA-based minimal residual disease assessment as a routine tool in lymphoma management.

Cite This Study

Piffaretti et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8ca4fhttps://doi.org/10.1182/bloodadvances.2024015609
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