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December 8, 2025Blood

Integration of longitudinal ctdna MRD and PET/CT enhances prognostic stratification in newly diagnosed diffuse large B-cell lymphoma: A prospective multicenter study

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Authors

SZShunjin ZhangXLXiao LiuDZDehui Zou

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Overview

Prospective study shows ctDNA tracking and PET/CT integration enhance prognostic assessment in DLBCL, indicating improved risk management.

Key Points

  • ctDNA monitoring revealed significant prognostic value, demonstrating improved progression-free survival rates.
  • Patients with elevated ctDNA showed poorer outcomes, with an adjusted hazard ratio of 4.87 after cycle one.
  • Prospective multicenter study utilized diagnostic plasma samples to assess ctDNA alongside PET/CT imaging.
  • Integration of ctDNA and imaging highlights the importance of dynamic monitoring in patient treatment plans.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236daeehttps://doi.org/10.1182/blood-2025-5323
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