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August 18, 2025AntioxidantsOpen Access

Mitochondrial Transfer Between Cancer and T Cells: Implications for Immune Evasion

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Authors

SCSung Hak ChunJAJin AnMKMan S. Kim

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Overview

Review reveals mitochondrial transfer as a tumor immune evasion strategy, suggesting its potential in CAR-T cell therapy.

Key Points

  • Mitochondrial transfer induces immune evasion, correlating with poor clinical outcomes.
  • Key metrics include mitochondrial-enabled reconstruction of cellular interactions and the tumor mitochondrial transfer score.
  • This review analyzes mitochondrial transfer mechanisms like tunneling nanotubes and extracellular vesicles.
  • Therapeutic transfer of healthy mitochondria can rejuvenate exhausted CAR-T cells, hinting at new treatment pathways.

Cite This Study

Chun et al. (2025) studied this question.

synapsesocial.com/papers/68af2ef6cf1dd9ea359e734fhttps://doi.org/10.3390/antiox14081008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial Transfer–Driven Immune Evasion in the Tumor Microenvironment2026
  2. 2Unveiling mitochondrial transfer in tumor immune evasion: mechanisms, challenges, and clinical implications2025
  3. 3Mitochondrial metabolism and cancer therapeutic innovation2025
  4. 4Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response2025 · 21 citations
  5. 5Mitochondria and Tumorigenesis2025