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July 14, 2025PLoS BiologyOpen Access

Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response

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Authors

YQYajing QiuYXYihan XuXDXinyuan Ding

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Overview

Research reveals metabolic reprogramming affects tumor microenvironment and T cell functions, suggesting new treatment strategies.

Key Points

  • MAIN FINDING: Bi-directional metabolic reprogramming impacts the anti-tumor immune response.
  • KEY EVIDENCE: Tumor-induced metabolic changes impair T cell function while adapted T cells influence tumor growth.
  • APPROACH: The study examines interactions within the tumor microenvironment that drive these metabolic adaptations.
  • SIGNIFICANCE: Understanding this crosstalk can identify new therapeutic targets for enhancing anti-tumor immunity.

Cite This Study

Qiu et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc39ahttps://doi.org/10.1371/journal.pbio.3003284
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