August 18, 2025Nature CommunicationsOpen Access

Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing

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Tissue furrow depth and bending behavior depend on RhoGEF recruitment, revealing critical biophysical principles.
Quantitative optogenetic perturbations show how basal actomyosin constrains furrow formation during gastrulation.
CRISPR/Cas9 was used to tag RhoGEF2, enabling light-dependent control of endogenous protein activities.
Findings highlight the potential of optogenetic tools to investigate developmental mechanics in epithelial tissues.

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Analysis demonstrates how Rho signaling influences tissue furrowing in Drosophila, suggesting insights for developmental biology.

Countryman et al. (2025) studied this question.

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