September 19, 2025Journal of Cell ScienceOpen Access

Regulation of cell shape and mechanics by Rho GEF/GAP in a proliferative epithelial tissue

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The study reveals how Rho GEFs and GAPs facilitate the control of epithelial cell shape through MyoII regulation.
Key findings include the identification of PlexA as a regulator of sensory organ precursor shape and junctional dynamics.
The analysis involved screening 28 Drosophila GAPs and 36 GEFs to determine their impact on MyoII distribution.
The results highlight important pathways linking actomyosin contractility to cell junction dynamics for epithelial homeostasis.

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Analysis identifies critical roles of Rho GEF and GAP in epithelial cell shape and MyoII regulation.

Durel et al. (2025) studied this question.

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