September 10, 2025NatureOpen Access

Patterned invagination prevents mechanical instability during gastrulation

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The cephalic furrow prevents mechanical instabilities by counteracting increased compressive stress during gastrulation.
In vivo experiments and in silico simulations show that mechanical forces influence embryonic morphogenesis in Drosophila.
Genetic comparisons indicate that changes in the transcription factor buttonhead relate to cephalic furrow evolution.
Findings suggest mechanical forces may drive the evolution of innovations in early embryonic development.

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This study demonstrates embryonic invagination's mechanical role in gastrulation, suggesting evolutionary implications for morphogenesis.

Vellutini et al. (2025) studied this question.

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