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August 18, 2025Antimicrobial Agents and ChemotherapyOpen Access

Synergistic interaction between praziquantel and oxfendazole or fenbendazole in a murine cysticercosis model

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Authors

PFPalomares-Alonso FranciscaAGAngélica González-MacielRRReynoso-Robles Rafael

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Overview

In vivo analysis shows praziquantel combined with oxfendazole or fenbendazole effectively reduces parasites in a murine cysticercosis model, suggesting potential clinical applications.

Key Points

  • Combination of praziquantel and oxfendazole shows an 11-fold increase in effectiveness against cysticercosis.
  • Twelve drug combinations exhibited synergism, highlighting potential for improved treatment options.
  • Observational analysis involved using a murine model to assess drug interactions and efficacy of combinations against Taenia crassiceps.
  • Findings suggest these combinations could lead to better clinical outcomes for neurocysticercosis treatment.

Cite This Study

Francisca et al. (2025) studied this question.

synapsesocial.com/papers/68af2eeacf1dd9ea359e6a5fhttps://doi.org/10.1128/aac.00560-25
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Also Consider

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  1. 1Evaluation of in Vitro Effects of Selected Pharmaceuticals on the Survival of Echinococcus Granulosus Protoscolices2025
  2. 2Optimizing the therapeutic benefits of synriam combined with praziquantel in mice harbouring juvenile and mature Schistosoma mansoni2025 · 2 citations
  3. 3High Efficacy of Triclabendazole/Ivermectin Combination Compared to Triclabendazole Monotherapy for Treating Human Fascioliasis in Upper Egypt: A Prospective Study2025
  4. 4Target-Based Design of Praziquantel Analogs at Cestode TRPM<sub>PZQ</sub>2025
  5. 5Activity of β-Caryophyllene Oxide and Benznidazole Mixture Against Trypanosoma cruzi and In Silico Prediction of Anti-Trypanocidal Interaction2025