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September 10, 2025ACS Infectious Diseases

Target-Based Design of Praziquantel Analogs at Cestode TRPMPZQ

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Authors

DSDaniel J. SpragueSPSang-Kyu ParkMKMarc Kaethner

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Overview

Target-based design improves praziquantel efficacy in pseudophyllidean cestodes, highlighting TRPM ion channels' role.

Key Points

  • This research shows that designing new praziquantel analogs can enhance effectiveness against resistant parasitic infections.
  • Key evidence indicates that the focus on TRPM channels allows for more targeted analgesic development against difficult parasites.
  • A target-based design approach highlights amino acid variations to inform thioamide derivative creation for better efficacy.
  • New analogs may significantly expand the anthelmintic toolbox, suggesting robust therapeutic strategies to combat parasitic flatworms.

Cite This Study

Sprague et al. (2025) studied this question.

synapsesocial.com/papers/68c24009b210217d647996efhttps://doi.org/10.1021/acsinfecdis.5c00449
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