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September 10, 2025Scientia PharmaceuticaOpen Access

Activity of β-Caryophyllene Oxide and Benznidazole Mixture Against Trypanosoma cruzi and In Silico Prediction of Anti-Trypanocidal Interaction

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Authors

LLLuis P. López-LópezNHNora Adriana Hernández‐CuevasKAKarla Y. Acosta-Viana

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Overview

In vitro analysis demonstrated significant synergistic activity against trypanosoma cruzi, suggesting implications for chagas disease therapy.

Key Points

  • The combination treatment reduced parasite viability by up to 80%, indicating substantial synergistic effects in vitro.
  • Testing showed that both β-caryophyllene oxide and benznidazole are hemocompatible with less than 5% hemolysis.
  • In silico predictions suggest β-caryophyllene oxide inhibits T. cruzi ABC channels, reinforcing its potential therapeutic role.
  • This combination treatment displays no cytotoxicity and supports further exploration in chagas disease management.

Cite This Study

López-López et al. (2025) studied this question.

synapsesocial.com/papers/68c24364b210217d647a6718https://doi.org/10.3390/scipharm93030040
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