Sex Differences in Neural Circuits Driving Binge Drinking

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Mapping neural activation in male and female mice reveals sex differences in binge drinking behavior.

Binge drinking in female mice increases neuronal activation in the basolateral amygdala, suggesting distinct neural pathways for alcohol consumption linked to sex.
Interregional correlation of brain activation showed basal differences between male and female mice in response to alcohol anticipation and consumption.
Analysis utilized chemogenetics to inhibit the basolateral amygdala, showcasing its functional role in reducing binge drinking behavior in female mice.
Understanding sex differences in these neural circuits may lead to targeted interventions for alcohol use disorder in women.

Maddern et al. (2025) studied this question.

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