Ghrelin Receptor Signalling in the Edinger-Westphal Nucleus Regulates Binge Drinking in a Sex-Specific Manner

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Investigation reveals that ghrelin receptor signalling impacts binge drinking in female mice, suggesting sex differences matter.

Ghrelin receptor involvement affects binge drinking behaviors differentially by sex, highlighting significant findings with females showing higher responsiveness.
Inhibition of EWcpCART cells led to reduced alcohol intake exclusively in female mice, demonstrating sex-specific neurobiological mechanisms.
Use of designer receptors and targeted knockdown methods confirmed the unique role of ghrelin receptors in mediating binge drinking.
Findings suggest that targeting ghrelin-related pathways may provide new therapeutic options for alcohol use disorder, especially for women.

Maddern et al. (2025) studied this question.

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