Observational analysis found distinct functional connectivity profiles in male and female mice, indicating sex differences in alcohol abuse disorder mechanisms.
Key Points
Alcohol consumption alters functional connectivity in the Nucleus Accumbens, highlighting its role in neuroplasticity changes.
Dynamic and stationary analyses revealed sex-dimorphism in brain connectivity related to alcohol consumption in mice.
The study utilized a translational murine model and multimodal-MRI to explore functional connectivity in alcohol abuse disorder.
Findings suggest the necessity for sex- and phenotype-adapted interventions in treating alcohol abuse disorder.