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September 10, 2025NeuropsychopharmacologyOpen Access

Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice

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Authors

CGCarol A. GianessiHHHarold L. HaunDPDipanwita Pati

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Overview

Operant self-administration reveals how corticotrophin releasing factor and GABA influence ethanol intake in male and female mice, suggesting distinct roles for each molecule.

Key Points

  • CRF deletion in BNST neurons reduces ethanol intake in both male and female mice, indicating strong sex-dependent effects.
  • Suppression of GABA release leads to increased ethanol self-administration and decreased motivation for sucrose, showing distinct regulatory roles.
  • The study utilized viral vectors to separate CRF and GABA effects on ethanol consumption in a controlled operant self-administration environment.
  • Findings suggest that BNST CRF release is crucial for intense ethanol drinking behaviors leading to dependence, while GABA affects motivation.

Cite This Study

Gianessi et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a5f7https://doi.org/10.1038/s41386-025-02192-2
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Also Consider

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  1. 1Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons2025
  2. 2Lateral hypothalamus CRFR1 regulation of chronic binge drinking: divergence along anterior-posterior axis2025
  3. 3Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons2025
  4. 4Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward2025
  5. 5Sex Differences in Low-dose Ethanol Effects on Motivated Behavior and Limbic Corticostriatal Activity2025