August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Raloxifene Induces Sex-Specific Changes in Anxiety- And Dopamine-Related Behaviours in Adolescent Offspring Following Prenatal Immune Activation

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Raloxifene treatment alters anxiety-related behaviours, with females showing more baseline activity than males.
Maternal immune activation reduced sensory motor responses in females, but responses differed from males and control groups.
Assessment involved various tests to measure anxiety and locomotion in offspring, with distinct outcomes based on sex and treatment.
Findings suggest that sex differences must be considered in clinical applications of raloxifene for neurodevelopmental outcomes.

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Implication

Experimental analysis reveals raloxifene influences anxiety and dopamine-related behaviours in male and female offspring, indicating sex-specific effects during adolescence.

Cite This Study

Costa et al. (2025) studied this question.

synapsesocial.com/papers/68af2ee5cf1dd9ea359e6706 https://doi.org/10.1093/ijnp/pyaf052.143

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Implication

Experimental analysis reveals raloxifene influences anxiety and dopamine-related behaviours in male and female offspring, indicating sex-specific effects during adolescence.

Raloxifene Induces Sex-Specific Changes in Anxiety- And Dopamine-Related Behaviours in Adolescent Offspring Following Prenatal Immune Activation

Key Points

Discussion

Implication

Cite This Study

Raloxifene Induces Sex-Specific Changes in Anxiety- And Dopamine-Related Behaviours in Adolescent Offspring Following Prenatal Immune Activation

Key Points

Discussion

Implication

Cite This Study

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