July 24, 2025

Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult Offspring

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Core finding illustrates maternal immune activation leads to depressive-like behaviors in adult offspring.
Behavioral tests show MIA offspring exhibited increased immobility in the forced swim test, especially in males.
Electrophysiological assessments reveal altered serotonin neuron firing rates in MIA-treated males.
This research contributes to understanding how maternal immune activation impacts neurodevelopmental risks for offspring.

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Implication

Preclinical evidence demonstrates maternal immune activation alters serotonin signaling and affects depressive-like behaviors in offspring, implying sex-dependent outcomes.

Cite This Study

Pistis et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdeef https://doi.org/10.21203/rs.3.rs-7131610/v1

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Implication

Preclinical evidence demonstrates maternal immune activation alters serotonin signaling and affects depressive-like behaviors in offspring, implying sex-dependent outcomes.

Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult Offspring

Key Points

Discussion

Implication

Cite This Study

Maternal Immune Activation with High Molecular Weight Poly (I:C) Induces Selective Depressive-Like Phenotype in Adult Offspring

Key Points

Discussion

Implication

Cite This Study

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