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April 1, 2025

Network Analysis and Structural Equation Modelling of Genetic and Environmental Factors in Hypertrophic Cardiomyopathy Progression

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Authors

SASaeed Ahmed AlawamiMAMohammed Hamzah A. AlshakhsRARenad Mohammad Alshahrani

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Overview

Network analysis demonstrates significant gene-environment interactions in hypertrophic cardiomyopathy, indicating improved risk stratification accuracy.

Key Points

  • HCM progression involves complex interactions between genetic and environmental factors, impacting treatment strategies.
  • The study identified gene-environment interactions that highlight the role of sarcomere mutations and environmental triggers in disease progression.
  • Comprehensive network analysis and structural equation modelling were applied to 50 patients to unveil critical disease mechanisms.
  • Results indicate improved risk stratification accuracy at 82%, surpassing traditional models by 17%, supporting customized clinical care.

Cite This Study

Alawami et al. (2025) studied this question.

synapsesocial.com/papers/68af2edecf1dd9ea359e6306https://doi.org/10.4103/atmr.atmr_58_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertrophic Cardiomyopathy: Current Perspectives2025
  2. 2Genetic insights into hypertrophic cardiomyopathy: pathogenesis, diagnosis, and therapeutic implications2025 · 9 citations
  3. 3Genetic, Clinical, and Sociodemographic Profile of Individuals with Diagnosis or Family History of Hypertrophic Cardiomyopathy: Insights from a Prospective Cohort2025 · 2 citations
  4. 4Mechanisms and Therapies of Hypertrophic Cardiomyopathy2025
  5. 5Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics2025 · 1 citations