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November 9, 2025Annual Review of Physiology

Mechanisms and Therapies of Hypertrophic Cardiomyopathy

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Authors

NPNiels PietschSSSonia R. SinghLCL. Carrier

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Overview

Review highlights biological mechanisms and targeted treatments for hypertrophic cardiomyopathy, suggesting genetics play a crucial role in patient management.

Key Points

  • Left ventricular hypertrophy is a key characteristic of hypertrophic cardiomyopathy, impacting heart function.
  • The review identifies a number of genetic variants linked with diastolic dysfunction and proteolysis in patients.
  • Molecular mechanisms contributing to hypertrophic cardiomyopathy include calcium handling and energy deficiency.
  • Understanding these mechanisms may facilitate targeted treatments for managing genetic variants in hypertrophic cardiomyopathy.

Cite This Study

Pietsch et al. (2025) studied this question.

synapsesocial.com/papers/690fdcdaf60c54d04ea37e9ehttps://doi.org/10.1146/annurev-physiol-042224-093244
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertrophic Cardiomyopathy: Current Perspectives2025
  2. 2Current and emerging medical and surgical therapy in hypertrophic cardiomyopathy2025
  3. 3Genetic insights into hypertrophic cardiomyopathy: pathogenesis, diagnosis, and therapeutic implications2025 · 9 citations
  4. 4Targeted Therapies in Hypertrophic Cardiomyopathy: A Practical Review of Evidence, Implementation, and Innovation2026
  5. 5INNOVATIVE DIAGNOSTIC TECHNOLOGIES AND TARGETED THERAPEUTICS IN HYPERTROPHIC CARDIOMYOPATHY: IMPLICATIONS FOR PERSONALIZED PATIENT CARE2025