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August 7, 2025Frontiers in Cell and Developmental BiologyOpen Access

Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics

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Authors

AIAyman M. IbrahimHEHasnaa A. ElfawyCTCesare M. Terracciano

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Overview

This review uncovers ECM remodeling in hypertrophic cardiomyopathy, suggesting novel diagnostics for personalized therapies.

Key Points

  • Heterogeneous presentations of hypertrophic cardiomyopathy create diverse clinical phenotypes.
  • Increased extracellular matrix remodeling and fibrosis impair myocardial function in patients.
  • Myocardial interstitial fibrosis results from complex interactions among cardiomyocytes and surrounding cells.
  • Identifying molecular targets may lead to improved diagnostics and targeted therapies for patients with HCM.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/689522069f4f1c896c42914chttps://doi.org/10.3389/fcell.2025.1641584
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T-Cell-Driven Immunopathology and Fibrotic Remodeling in Hypertrophic Cardiomyopathy: A Translational Scoping Review2025 · 3 citations
  2. 2Transcriptomic remodeling in gene-negative hypertrophic cardiomyopathy revealed by single-nucleus RNA sequencing2026
  3. 3Network Analysis and Structural Equation Modelling of Genetic and Environmental Factors in Hypertrophic Cardiomyopathy Progression2025
  4. 4Mechanisms and Therapies of Hypertrophic Cardiomyopathy2025
  5. 5Hypertrophic Cardiomyopathy: Current Perspectives2025