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September 10, 2025British Journal of CancerOpen Access

Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women

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Authors

TWTengteng WangOZOana A. ZeleznikEMEmma E. McGee

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Overview

Matched case-control study identifies associations of metabolomic profiles with breast cancer incidence, suggesting potential biomarkers.

Key Points

  • Six lipid-related metabolites showed significant associations with breast cancer incidence in premenopausal women.
  • Conditional logistic regression revealed distinct odds ratios for lipid and phosphocholine metabolites linked to breast cancer.
  • Metabolite set enrichment analysis indicated triglycerides and phosphatidylcholine were inversely associated with cancer incidence.
  • Further validation in diverse populations is necessary to confirm these findings on metabolomic biomarkers.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786db9https://doi.org/10.1038/s41416-025-03159-2
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