September 10, 2025

A cytotoxic gene therapy targeting SOX9-positive therapy-resistant medulloblastoma

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Gene therapy using SOX9-specific elements reduces therapy resistance in medulloblastoma, highlighting a novel approach.

Cytotoxic gene therapy effectively eliminates SOX9-positive medulloblastoma cells in vitro and in vivo.
Using an AAV vector expressing HSV-TK, ganciclovir selectively kills therapy-resistant tumor cells expressing SOX9.
SOX9-driven therapy shows potential synergy with standard treatments like fractionated radiation for pediatric tumors.
Four tandem S9REs coupled with a minimal promoter were used to label SOX9-active cells for targeted therapy.

Lin et al. (2025) studied this question.

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September 10, 2025

View Full Paper

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Authors

Gene therapy using SOX9-specific elements reduces therapy resistance in medulloblastoma, highlighting a novel approach.

Cytotoxic gene therapy effectively eliminates SOX9-positive medulloblastoma cells in vitro and in vivo.
Using an AAV vector expressing HSV-TK, ganciclovir selectively kills therapy-resistant tumor cells expressing SOX9.
SOX9-driven therapy shows potential synergy with standard treatments like fractionated radiation for pediatric tumors.
Four tandem S9REs coupled with a minimal promoter were used to label SOX9-active cells for targeted therapy.

Lin et al. (2025) studied this question.

View Full Paper

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Bookmark