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August 10, 2025PharmaceuticsOpen Access

Recent Advances in Nanomedicine: Cutting-Edge Research on Nano-PROTAC Delivery Systems for Cancer Therapy

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Authors

XWXiaoqing WuYSYueli ShuZYZheng Yao

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Overview

This review highlights developments in nano-PROTACs delivery for cancer therapy, indicating their potential to overcome traditional drug limitations.

Key Points

  • The integration of nanocarriers improves solubility and stability of PROTACs, enhancing cancer treatment efficacy.
  • Recent advances showcase different delivery strategies, particularly in targeting tumors with minimized side effects.
  • A variety of nanomaterials, including lipid-based and polymeric nanoparticles, exhibit significant potential for PROTACs delivery.
  • These innovations hold promise for overcoming current challenges in clinical translation of PROTACs.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68af2695cf1dd9ea359e2529https://doi.org/10.3390/pharmaceutics17081037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nanotechnology-Based Strategies for Overcoming Clinical Limitations of PROTACs in Cancer Therapy2025
  2. 2Proteolysis Targeting Chimera (PROTACs) in Cancer: From Molecular Mechanisms to Therapeutic Opportunities2025
  3. 3Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions2025
  4. 4Ionizable Nano‐PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression2025
  5. 5Recent Advances in the Development of Pro-PROTAC for Selective Protein Degradation2025 · 11 citations