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November 28, 2025Angewandte Chemie International Edition

Ionizable Nano‐PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression

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Authors

HMHuan MinMSMing Chao SunKHKai-jing Hu

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Overview

Nano‐PROTAC technology degrades LRG1 and induces tumor regression in murine models, suggesting therapeutic promise.

Key Points

  • Enhanced degradation of LRG1 leads to significant tumor regression and apoptosis induction.
  • The novel nano‐PROTAC design integrates a tertiary-amine motif for improved cytosolic delivery and endosomal escape.
  • Analysis focused on 4T1 murine breast tumors reveals effective tumor suppression without systemic toxicity.
  • Highlights a promising strategy to overcome endosomal entrapment in protein degradation therapies.

Cite This Study

Min et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79b33https://doi.org/10.1002/anie.202520235
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  4. 4Proteolysis Targeting Chimera (PROTACs) in Cancer: From Molecular Mechanisms to Therapeutic Opportunities2025
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