Review highlights recent strategies in pro-PROTAC development for improved target protein delivery, indicating enhanced precision and clinical utility.
Key Points
Pro-PROTACs improve target protein delivery and efficacy in degradation via selective ubiquitination.
Recent advancements aim to enhance the precision of PROTAC technology, achieving better on-target exposure.
The ubiquitin-proteasome system plays a critical role in protein degradation following PROTAC action.
Challenges remain in the design of PROTACs, particularly in addressing duration of action and specificity.