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August 15, 2025BMC Global and Public HealthOpen Access

Genomic sequencing surveillance of patients colonized with vancomycin-resistant enterococci improves detection of healthcare-associated transmission

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Authors

ASAlexander SundermannVSVatsala Rangachar SrinivasaEMEmma G. Mills

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Overview

Whole genome sequencing uncovers transmission dynamics of vancomycin-resistant enterococci in healthcare settings, suggesting improved infection control strategies.

Key Points

  • Whole genome sequencing improved the detection of vancomycin-resistant enterococci transmission, revealing significant clusters and hotspots.
  • Rectal carriage accounted for 87.3% of VRE acquisition, with a monthly rate of 7.6 cases per 1000 patient days.
  • Analysis of 352 clinical isolates over 34 months highlighted the contribution of colonizing isolates to VRE spread in healthcare settings.
  • Incorporating genomic surveillance into routine practices may enhance infection prevention measures and patient safety.

Cite This Study

Sundermann et al. (2025) studied this question.

synapsesocial.com/papers/68a34f63234c60ad5c20bbbchttps://doi.org/10.1186/s44263-025-00186-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surveillance and Characterization of Vancomycin-Resistant and Vancomycin-Variable Enterococci in a Hospital Setting2025
  2. 2Culture-enriched metagenomic sequencing reveals within-patient diversity and transmission of vancomycin-resistant Enterococcus faecium2026
  3. 3Comparative core-genome MLST of vancomycin-resistant Enterococcus faecium supports the utility of wastewater-based surveillance: a pilot study2026
  4. 4Investigation and experience sharing of increased Vancomycin-Resistant Enterococcus (VRE) cases in adult intensive care units of hospitals in southern Taiwan2025
  5. 5Asymptomatic faecal carriage of vancomycin-resistant Enterococci among inpatients and outpatients in a Kenyan hospital: a cross-sectional study2025