September 5, 2025Open Access

NGAL drives cardiac dysfunction and fibrosis in rats with chronic kidney disease

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Observational analysis reveals that Ngal drives cardiac dysfunction and fibrosis in CKD rats, suggesting Gal-3's role in this process.

Cardiac dysfunction was less severe in CKD Ngal knockout rats compared to wild-type counterparts.
High levels of Gal-3 and collagen I were noted in cardiac fibroblasts exposed to recombinant Ngal.
Ngal activation of the Tlr4-Myd88 pathway was linked to increased cardiac fibrosis and inflammation.
Elevated Ngal and Gal-3 levels correlated with diastolic dysfunction and poor outcomes in CKD patients.

Soulié et al. (2025) studied this question.

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September 5, 2025Open Access

View Full Paper

Ask AI

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Authors

Observational analysis reveals that Ngal drives cardiac dysfunction and fibrosis in CKD rats, suggesting Gal-3's role in this process.

Cardiac dysfunction was less severe in CKD Ngal knockout rats compared to wild-type counterparts.
High levels of Gal-3 and collagen I were noted in cardiac fibroblasts exposed to recombinant Ngal.
Ngal activation of the Tlr4-Myd88 pathway was linked to increased cardiac fibrosis and inflammation.
Elevated Ngal and Gal-3 levels correlated with diastolic dysfunction and poor outcomes in CKD patients.

Soulié et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark