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August 5, 2025Signal Transduction and Targeted TherapyOpen Access

Cancer stem cells: landscape, challenges and emerging therapeutic innovations

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Authors

HLHaksoo LeeBKByeongsoo KimJPJunhyeong Park

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Overview

This review highlights challenges in targeting cancer stem cells in tumors, suggesting innovative therapeutic strategies for improved treatment outcomes.

Key Points

  • Cancer stem cells are a crucial subpopulation within tumors that contributes to treatment resistance and tumor growth.
  • Metabolic plasticity in cancer stem cells allows them to adapt to various environmental conditions, enhancing survival.
  • Recent investments in single-cell sequencing and AI-driven multiomics are vital for developing effective therapies targeting cancer stem cells.
  • Challenges in identifying reliable biomarkers and targeting cancer stem cells without affecting normal cells remain significant hurdles.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d1025https://doi.org/10.1038/s41392-025-02360-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cancer stem cells in personalized therapy: mechanisms, microenvironment crosstalk, and therapeutic vulnerabilities2025 · 16 citations
  2. 2Cancer stem cells in focus: Deciphering the dynamic functional landscape of stemness in cancer2025 · 11 citations
  3. 3Advances in Nanomedicine for Targeting Cancer Stem Cells and Overcoming Therapeutic Resistance2025 · 11 citations
  4. 4Cancer stem cell-driven drug resistance in colorectal carcinoma: molecular aspects and therapeutic potentials2026 · 18 citations
  5. 5Recent Advances in the Understanding of CSCs and Treatments Targeting Them2024