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September 10, 2025Biochimica et Biophysica Acta (BBA) - Reviews on CancerOpen Access

Cancer stem cells in focus: Deciphering the dynamic functional landscape of stemness in cancer

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Authors

GNGabriel C. NwokoloTGTrivadi S. GanesanKPKlaus Pors

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Overview

This review uncovers the complex regulation of cancer stem cells, highlighting plasticity and implications for targeted therapies.

Key Points

  • Cancer stem cells display dynamic functional states, enabling tumor initiation and relapse with metabolism variations, suggesting a fluid identity.
  • Epigenetic reprogramming, intrinsic programs, and environmental factors drive the flexible behavior of cancer stem cells.
  • Inconsistencies in marker expression impede the effective targeting of cancer stem cells, complicating therapeutic approaches.
  • Identifying actionable vulnerabilities in the cancer stem cell landscape is crucial for advancing targeted therapies and overcoming resistance.

Cite This Study

Nwokolo et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787bb1https://doi.org/10.1016/j.bbcan.2025.189440
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